Uterine Fibroids Clinical Trials

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Bilateral Uterine Artery Ligation Versus Pericervical Mechanical Tourniquet Application in Reducing Intraoperative Blood Loss During Transabdominal Myomectomy.

Status: Recruiting
Location: See location...
Intervention Type: Procedure
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The goal of this clinical trial is to compare two surgical techniques for reducing blood loss during transabdominal myomectomy in women with symptomatic uterine fibroids. The main question it aims to answer is whether bilateral uterine artery ligation reduces intraoperative blood loss more effectively than pericervical mechanical tourniquet application, without increasing operative complications. Researchers will compare bilateral uterine artery ligation with pericervical mechanical tourniquet application during open myomectomy to evaluate blood loss and surgical safety. Participants will undergo elective transabdominal myomectomy and will be randomly assigned to one of the two vascular control techniques before myoma enucleation.

Eligibility
Participation Requirements
Sex: Female
Minimum Age: 25
Maximum Age: 48
Healthy Volunteers: f
View:

⁃ Female participants aged 25 to 48 years

• Body mass index less than 35 kg/m²

• Symptomatic uterine myomas requiring surgical treatment

• Intramural myomas classified as FIGO types 3 to 6

• Diagnosis confirmed by transvaginal ultrasound and/or magnetic resonance imaging

• Maximum diameter of the largest myoma 20 cm or less

• Scheduled for elective transabdominal myomectomy

• Able and willing to provide written informed consent

Locations
Other Locations
Egypt
Cairo University
RECRUITING
Cairo
Contact Information
Primary
Maged Elmohamady Rashedy, MD
Magedalmohamady50@gmail.com
01090013685
Time Frame
Start Date: 2026-04-10
Estimated Completion Date: 2027-04-10
Participants
Target number of participants: 40
Treatments
Experimental: Bilateral Uterine Artery Ligation
Participants assigned to this arm will undergo transabdominal myomectomy with bilateral uterine artery ligation performed before myoma enucleation. The uterine arteries will be identified bilaterally near the level of the internal cervical os and ligated using absorbable sutures to reduce uterine blood flow during surgery. Myoma enucleation and uterine repair will then be completed according to the study protocol.
Experimental: Pericervical Mechanical Tourniquet
Participants assigned to this arm will undergo transabdominal myomectomy with application of a pericervical mechanical tourniquet before myoma enucleation. A sterile Foley catheter will be passed around the cervico-isthmic region at the level of the internal os and tied firmly to compress the uterine vessels during surgery. The tourniquet will remain in place throughout myoma enucleation and uterine repair and will be removed after completion of hemostasis.
Related Therapeutic Areas
Sponsors
Collaborators: Kafrelsheikh University
Leads: Cairo University

This content was sourced from clinicaltrials.gov